PUBLICATIONS

1. Fok AHK, Huang Y, So BWL, Zheng Q, Tse CSC, Li X, Wong KKY, Huang J, Lai KO*, and Lai CSW* (2024). KIF5B plays important roles in dendritic spine plasticity and dendritic localization of PSD95 and FMRP in the mouse cortex in vivo. Cell Rep. 43: 113906. DOI: 10.1016/j.celrep.2024.113906

 

2. Dong R, Li X, Flores AD, Lai KO* (2023). The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons. J. Biol. Chem. 299 (8): 105029. DOI: 10.1016/j.jbc.2023.105029.

 

​3. Lo LHY, Dong R, Lyu Q and Lai KO* (2020). The protein arginine methyltransferase PRMT8 and substrate G3BP1 control Rac1-PAK1 signaling and actin cytoskeleton for dendritic spine maturation. Cell Rep. 31: 107744. DOI: 10.1016/j.celrep.2020.107744. Featured in Croucher Foundation News https://projects.croucher.org.hk/news/how-connections-in-the-brain-change-over-time

 

4. ​Zhao J, Fok AHK, Fan R, Kwan PY, Chan HL, Lo HY, Chan YS, Yung WH, Huang J, Lai CSW*, Lai KO* (2020). Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory. eLife. 9: e53456. DOI: 10.7554/eLife.53456. Featured in Research Highlights in Nature Reviews Neuroscience https://www.nature.com/articles/s41583-020-0272-8 and eLife Digest https://elifesciences.org/digests/53456/going-the-distance

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5. Lin LF, Lyu Q, Kwan PY, Zhao J, Fan R, Chai A, Lai CSW, Chan YS, Shen X, Lai KO* (2020). The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors. PLoS Genet. 16: e1008587. DOI: 10.1371/journal.pgen.100858.7 Featured in Croucher Science Week Blog https://croucherscienceweek.hk/research-discoveries/unlocking-the-role-of-tbc1d24-protein-in-our-brain/

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6. Lin LF, Lo HY, Lyu Q, Lai KO* (2017) Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A. J. Biol. Chem. 292 (23): 9451-9464.

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7. Liang Z, Zhan Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY (2016) The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines. Nat. Commun. 7:13282. DOI: 10.1038/ncomms13282.

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8. Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH (2016) Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Sci. Signal. 9 (444): ra89. DOI: 10.1126/scisignal.aaf1371.

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9. Lai KO*, Liang ZY, Fei E, Huang H, Ip NY* (2015) Cdk5-dependent phosphorylation of p70 ribosomal S6 kinase (S6K) is required for dendritic spine morphogenesis. J. Biol. Chem. 290 (23):14637-46. DOI: 10.1074/jbc.M114.627117

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10. Liang Z, Ye T, Zhou X, Lai KO, Fu AKY, Ip NY. (2015). Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. J. Neurosci. 35 (45): 15127–15134. DOI: 10.1523/JNEUROSCI.1443-15.2015

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11. Lai KO, Wong ASL, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY. (2012) Serine phosphorylation of TrkB by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat. Neurosci. 15 (11): 1506–1515. DOI: 10.1038/nn.3237. Featured in News and Views of Nature Neuroscience (http://www.nature.com/neuro/journal/v15/n11/full/nn1112-1474.html), Editor’s choice of Science Signaling (http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/249/ec287) and Faculty 1000 Biology (http://f1000.com/prime/717968360)

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12. Lai KO, Zhao Y, Ch’ng TH, Martin KC (2008) Importin-mediated retrograde transport of CREB2/ATF4 from distal processes to the nucleus in neurons. Proc. Natl. Acad. Sci. U.S.A. 105 (44): 17175-17180. DOI: 10.1073/pnas.0803906105. Highlighted by the Faculty 1000 Biology https://facultyopinions.com/prime/1138064